Table of Contents
Cover
Title Page
Copyright
List of Contributors
Foreword
Preface
Part I: Fundamentals
Chapter 1: Introduction to Tissue Engineering
1.1 Introduction
1.2 Clinical Need for Tissue Engineering and Regenerative Medicine
1.3 History of Tissue Engineering and Regenerative Medicine
1.4 Fundamentals of Tissue Engineering and Regenerative Medicine
1.5 Applications of Tissue Engineering
1.6 Challenges in Tissue Engineering
1.7 The Future of Tissue Engineering
1.8 Conclusions
References
Chapter 2: Biomaterials in Tissue Engineering
2.1 Introduction
2.2 Biomaterial–Tissue Interactions
2.3 Properties of Biomaterials
2.4 Scaffold Requirements for Specific Tissues
2.5 Classification of Biomaterials
2.6 Fabrication Methods of Biomaterials
2.7 Testing of Biomaterials
2.8 Challenges for Biomaterials in Tissue Engineering
2.9 Conclusions and Future Directions
Acknowledgment
Abbreviations
References
Chapter 3: Harnessing the Potential of Stem Cells from Different Sources for Tissue Engineering
3.1 Introduction
3.2 Stem Cells in Tissue Engineering
3.3 Unique Properties
3.4 Types of Stem Cells
3.5 Application of Stem Cells in Tissue Engineering
3.6 Challenges and Future Directions
3.7 Conclusion
Acknowledgments
References
Chapter 4: Induced Pluripotent Stem Cells in Scaffold-Based Tissue Engineering
4.1 Introduction
4.2 Basics of Induced Pluripotent Stem Cells
4.3 Concept of Scaffold-Based Tissue Engineering
4.4 Cell–Scaffold Interactions
4.5 Application of Induced Pluripotent Stem Cells
4.6 Concluding Remarks
Acknowledgments
References
Chapter 5: Biosensors for Optimal Tissue Engineering: Recent Developments and Shaping the Future
5.1 Introduction
5.2 Fundamentals of Biosensors
5.3 Biosensing Techniques
5.4 Real-Time Sensing in Tissue Engineering and Cell Growth
5.5
In Vivo
Implementations and the Challenges Faced
5.6 Conclusion and Future Directions
References
Chapter 6: Bioreactors in Tissue Engineering
6.1 Introduction
6.2 Bioreactors
6.3 Applications of Bioreactors in Tissue Engineering
6.4 Summary and Future Perspectives
Acknowledgment
Abbreviations
References
Part II: Applications
Chapter 7: Tissue-Engineered Human Skin Equivalents and Their Applications in Wound Healing
7.1 Introduction
7.2 Development of Tissue-Engineered Human Skin Equivalents
7.3 Application of TESs in Wound Healing
7.4 Conclusions and Future Directions
Acknowledgments
References
Chapter 8: Articular Cartilage Tissue Engineering
8.1 Introduction
8.2 Articular Cartilage Lesions and Repair
8.3 Basics of Articular Cartilage Tissue Engineering
8.4 Strategies in Current Cartilage Tissue Engineering
8.5 Conclusions and Future Directions
List of Abbreviations
References
Chapter 9: Liver Tissue Engineering
9.1 Introduction
9.2 Liver Biology
9.3 Liver Biomechanics
9.4 Liver Mechanobiology
9.5 Biophysical Stimuli in Liver Tissue Engineering Scaffolds
9.6 Conclusion and Future Directions
References
Chapter 10: Development of Tissue-Engineered Blood Vessels
10.1 Introduction
10.2 Biology of Blood Vessels
10.3 Tissue Engineering of Blood Vessels
10.4 Conclusion and Perspective
Acknowledgment
References
Chapter 11: Engineering Trachea and Larynx
11.1 Introduction
11.2 Basic Anatomy and Histology of the Larynx and Trachea
11.3 Indications for Tracheal Resection
11.4 Available Remedies Following Total Laryngectomy
11.5 Regenerative Medicine Strategies and Tissue Engineering Tools for Tracheal and Larynx Replacement
11.6 Conclusions and Future Directions
Declaration/Conflict of Interest
References
Chapter 12: Pulmonary Tissue Engineering
12.1 Introduction
12.2 Clinical Need for Pulmonary Tissue Engineering
12.3 Structure–Function Relationship in the Conducting Airways and the Lung
12.4 Tissue Engineering and Regenerative Medicine: Approaches for the Lung
12.5 Conclusions, Remaining Challenges, and Future Directions
References
Chapter 13: Cardiac Tissue Engineering
13.1 Introduction
13.2 Cardiac Tissue Architecture
13.3 Cell Source Considerations
13.4 Engineering for Myocardial Tissue
13.5 Conclusion and Future Directions
References
Chapter 14: Approaches and Recent Advances in Heart Valve Tissue Engineering
14.1 Introduction
14.2 Principles of Tissue Engineering: Shaping the Valvular Construct
14.3
In Vitro
Bioengineering of Heart Valves: Scaffold Materials
14.4 Cells for Valvular Bioengineering
14.5 Challenges and Limitations
14.6 Conclusion and Future Directions
References
Chapter 15: Musculoskeletal Tissue Engineering: Tendon, Ligament, and Skeletal Muscle Replacement and Repair
15.1 Introduction
15.2 Biology of Tendon, Ligament, and Skeletal Muscle
15.3 Grafting Practices for Tendon, Ligament, and Skeletal Muscle Repair
15.4 Factors in Musculoskeletal Tissue Engineering
15.5 Recent Advancements in Musculoskeletal Tissue Engineering
15.6 Conclusions and Future Directions
References
Chapter 16: Bone Tissue Engineering: State of the Art, Challenges, and Prospects
16.1 Introduction
16.2 Factors Important in Tissue Engineering of Bone
16.3 Fabricated Tissues by 3D Printing of Suspensions of Cells on Micro-Carriers
16.4 Recent Advances in Bone Tissue Engineering
16.5 Conclusion and Future Prospects
References
Chapter 17: Tissue Engineering of the Pancreas
17.1 Introduction
17.2 Treatment Options for T1D
17.3 Bioartificial Pancreas
17.4 Biomaterials/Encapsulation
17.5 Conclusion
References
Chapter 18: Tissue Engineering of Renal Tissue (Kidney)
18.1 Introduction
18.2 Biology of the Kidney
18.3 Overview of Kidney Development and Vascularization
18.4 Developmental Engineering
18.5 Bio-Scaffold-Based Technologies
18.6 Conclusions and Future Directions
Acknowledgments
References
Chapter 19: Design and Engineering of Neural Tissues
19.1 Introduction
19.2 Natural Biomaterials for Nerve Tissue Repair
19.3 Synthetic Biomaterials for Nerve Tissue Repair
19.4 Development of Nanofibrous Scaffolds
19.5 Summary and Future Direction
References
Chapter 20: Neural-Tissue Engineering Interventions for Traumatic Brain Injury
20.1 Introduction
20.2 Neurogenesis in CNS: Resident Neural Stem Cells
20.3 Cell-Based and Neuroprotection Therapeutic Strategies
20.4 Construct Technology: Biomaterials Approach
20.5 Application to Living System: Translational Approaches
20.6 Future Outlook: Transition to the Clinic
Abbreviations
References
Chapter 21: Bionics in Tissue Engineering
21.1 Introduction
21.2 Electronics for Biointerfaces
21.3 Novel Power Sources
21.4 3D Printing
21.5 Conclusions and Future Directions
References
Index
End User License Agreement
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Guide
Cover
Table of Contents
Foreword
Preface
Part I: Fundamentals
Begin Reading