Details

Insulin Resistance

Childhood Precursors and Adult Disease
Contemporary Endocrinology

von: Philip Scott Zeitler, Kristen J. Nadeau
213,99 €
Verlag:	Humana Press
Format:	PDF
Veröffentl.:	28.12.2008
ISBN/EAN:	9781597451925
Sprache:	englisch
Anzahl Seiten:	331

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Beschreibungen

Titelbeschreibung

In the mid 1990s, Drs. Gerald Reaven identified a constellation of clinical findings, known variously as the metabolic syndrome, syndrome X, insulin resistance s- drome or insulin resistance-related disorders, that are associated with an increased risk of heart disease and diabetes. Interest in this topic grew rapidly, culminating in the publication by this series of the book, Insulin Resistance and the Metabolic Syndrome X, edited by Drs. Reaven and Laws in 1999. Since the original publication of that now classic volume, the world’s population has continued to become more obese and sedentary and the prevalence of disorders related to insulin resistance has continued to increase throughout the developed and developing world. Of great concern in the last decade is the extension of these deleterious lifestyle patterns to the pediatric population, leading to both obesity and the appearance of insulin resistance-related disorders in youth as well as adults. Today, about one in three children and adolescents in the United States is overweight or obese, and this prevalence approaches one in two among adolescents in certain minority groups. In addition, components of this cardiovascular risk constellation are now being recognized in young adults, adolescents, and even children. Youth are increasingly developing type 2 diabetes, fatty liver disease, hypertriglyceridemia, hypertension, polycystic ovarian syndrome, sleep apnea, orthopedic and psychiatric complications, as well as other complications of obesity and insulin resistance.

Inhaltsverzeichnis

Epidemiology.- The Metabolic Syndrome: Definitions, Controversies and Clinical Utility.- Epidemiology of the Metabolic Syndrome and Related Disorders in Children and Adolescents.- Metabolic Syndrome in Children and Adolescents Worldwide.- Maternal-Fetal Contributors to the Insulin Resistance Syndrome in Youth.- Early Childhood Contributions to Insulin Resistance.- Pathophysiology.- Molecular Mechanisms of Insulin Resistance.- Techniques Used to Assess Insulin Action.- Adiposity is The Enemy: Body Composition and Insulin Sensitivity.- Ectopic Fat Deposition, Adiponectin and Insulin Resistance in Obese Adolescents.- Mediators of Insulin Resistance.- Insulin Resistance and the Pathogenesis of Cardiovascular Disease.- Insulin Resistance and Cardiovascular Disease.- The Liver and Insulin Resistance: The Important Convergence of Endocrinology and Hepatology.- Polycystic Ovary Syndrome and Metabolic Syndrome.- Treatment.- Effects of Exercise in Metabolic Syndrome and Diabetes: A Central Role for Insulin Sensitivity.- Weight Loss Medications and the Metabolic Syndrome.

Back cover copy

The prevalence of disorders related to insulin resistance has continued to increase throughout the developed and developing world. The world’s population has continued to become more obese and sedentary. Of great concern in the last decade is the extension of these deleterious lifestyle patterns to the pediatric population, leading to both obesity and the appearance of insulin resistance-related disorders in youth as well as adults. Insulin Resistance: Childhood Precursors and Adult Disease presents topics related to insulin resistance and its consequences across the lifespan. In the first section of the book examining epidemiology, the contributors review controversies over the definition of metabolic syndrome in adults and children, current knowledge regarding the epidemiology of insulin resistance in the pediatric population and the contributions of the prenatal and early childhood environment to the development of insulin resistance. The Second part of the book explores pathophysiology, with reviews of the techniques used to study insulin resistance, as well as current knowledge of the molecular and physiologic mechanisms of insulin resistance, including the contributions of adipose tissue and biochemical mediators. This section concludes with discussion of the relationship between insulin resistance and cardiovascular, endothelial, liver and gonadal disorders. The final section of the book explores the impact of exercise and weight loss medications on insulin resistance. Insulin resistance is likely to be the most important public health concern in many parts of the world in coming decades. This volume provides up-to-date reviews of these areas, providing the reader with a current perspective on issues in insulin resistance as they affect patients across the lifespan. The hope for Insulin Resistance: Childhood Precursors and Adult Disease is that it will spur continued interest in the topic on the part of clinicians and researchers,perhaps promoting new points of view and creative approaches to a daunting challenge.

Sonderbeitrag

State-of-the-art perspective on insulin resistance by renowned experts in the field Topics cover insulin resistance and its consequences across the lifespan Reviews controversies over the definition of metabolic syndrome in adults and children Addresses current knowledge regarding the epidemiology of insulin resistance in the pediatric population Examines views on prenatal and early childhood environment to the development of insulin resistance Explores pathophysiology, with reviews of the techniques used to study insulin resistance Provides an overview of current knowledge of the molecular and physiologic mechanisms of insulin resistance, including the contributions of adipose tissue and biochemical mediators Discusses the relationship between insulin resistance and cardiovascular, endothelial, liver and gonadal disorders Explores the impact of exercise and weight loss medications on insulin resistance

Verkaufsargumente

Over the last few years, the understanding of metabolic syndrome has advanced in a number of directions. This book provides an update on the current status of the understanding of insulin resistance and metabolic syndrome in children and adults. There is particular focus on childhood precursors of the disorder (fetal, perinatal, and childhood factors) since this is an area of great promise for prevention of future expansion of the epidemic. The book is divided into three major sections - epidemiology, pathophysiology, and intervention (both pharmacologic and lifestyle) in both adults and children.