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Advances in Metallodrugs

Preparation and Applications in Medicinal Chemistry
1. Aufl.

von: Shahid Ul-Islam, Athar Adil Hashmi, Salman Ahmad Khan
213,99 €
Verlag:	Wiley
Format:	PDF
Veröffentl.:	21.05.2020
ISBN/EAN:	9781119641018
Sprache:	englisch
Anzahl Seiten:	432

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Beschreibungen

Titelbeschreibung

This book is organized into 12 important chapters that focus on the progress made by metal-based drugs as anticancer, antibacterial, antiviral, anti-inflammatory, and anti-neurodegenerative agents, as well as highlights the application areas of newly discovered metallodrugs. It can prove beneficial for researchers, investigators and scientists whose work involves inorganic and coordination chemistry, medical science, pharmacy, biotechnology and biomedical engineering.

Inhaltsverzeichnis

Preface xiii 1 Metallodrugs in Medicine: Present, Past, and Future Prospects 1 Imtiyaz Yousuf and Masrat Bashir 1.1 Introduction 2 1.2 Therapeutic Metallodrugs 6 1.2.1 Anticancer Metallodrugs 6 1.2.1.1 Mechanism of Anticancer Action 7 1.2.2 Antimicrobial and Antiviral Metallodrugs 15 1.2.2.1 Antimicrobial Metallodrugs 15 1.2.2.2 Antiviral Metallodrugs 16 1.2.3 Radiopharmaceuticals and Radiodiagnostic Metallodrugs 17 1.2.4 Anti-Diabetic Metallodrugs 19 1.2.5 Catalytic Metallodrugs 22 1.3 Future Prospects 23 1.4 Conclusion 25 References 26 2 Chemotherapeutic Potential of Ruthenium Metal Complexes Incorporating Schiff Bases 41 Manzoor Ahmad Malik, Parveez Gull, Ovas Ahmad Dar, Mohmmad Younus Wani, Md Ikbal Ahmed Talukdar and Athar Adil Hashmi 2.1 Introduction 42 2.2 Schiff Base Complexes of Ruthenium as Anticancer Agents 43 2.3 Conclusion 63 References 64 3 Role of Metallodrugs in Medicinal Inorganic Chemistry 71 Manish Kumar, Gyanendra Kumar, Arun Kant and Dhanraj T. Masram 3.1 Introduction 72 3.2 Platinum Anticancer Drugs 74 3.2.1 Nucleophilic Displacement Reactions in Complexes of Platinum 80 3.2.2 Mode of the Interaction of Cisplatin Species With Nitrogen Donors of DNA Strand 80 3.2.3 Systemic Toxicity of Cisplatin 82 3.3 Copper-Based Anticancer Complexes 82 3.3.1 Copper is Essential for Health and Nutrition 82 3.3.2 Healthcare Applications of Copper 83 3.3.3 Copper and Human Health Disorders 83 3.3.3.1 Wilson’s Disease (WD) 84 3.3.3.2 Menkes’ Disease 85 3.3.4 Role of Copper Complexes as Potential Therapeutic Agents 85 3.3.4.1 Thiosemicarbazones-Based Complexes 86 3.3.4.2 Quinolones-Based Copper Complexes 88 3.3.4.3 Naphthoquinones 88 3.4 Zinc Anticancer Complexes 89 3.4.1 Biologically Importance of Zinc 90 3.4.2 Schiff Base Chemistry 92 3.4.2.1 Schiff Base and Their Metal Complexes 92 3.4.3 Zinc-Based Complexes 93 3.4.4 Top Food Sources of Zinc 94 3.4.5 Role of Zinc in Human Body 97 3.4.6 Zinc as a Health Benefit 98 3.4.7 Zinc in Alloy and Composites 100 3.4.8 Zinc Supplementation as a Treatment 100 3.4.8.1 Zinc Deficiency 101 3.4.8.2 Zinc Toxicity 102 3.4.8.3 Zinc and Viral Infections 102 3.4.9 Gastrointestinal Effects 103 3.5 Future Prospects of Metallodrugs 103 References 104 4 Ferrocene-Based Metallodrugs 115 Hamza Shoukat, Ataf Ali Altaf and Amin Badshah 4.1 Introduction 115 4.2 Ferrocene-Based Antimalarial Agents 117 4.2.1 Mechanism of Action 118 4.3 Ferrocene-Based Antibacterial and Antifungal Drugs 118 4.3.1 Schiff Base Derived Ferrocene Conjugates as Antibacterial Agents 119 4.3.2 Ferrocenyl Guanidines as Antibacterial and Antifungal Agents 121 4.3.3 Sedaxicene as Antifungal Agents 122 4.4 Ferrocene-Based Anti-Tumor and Anti-Cancerous Drugs 123 4.4.1 Ferricenium Salts as Anti-Tumor Agents 124 4.4.2 Ferrocenylalkylazoles Active Anti-Tumor Drugs 124 4.4.3 Ferrocene Conjugated to Peptides for Lung Cancer 125 4.4.4 Ferrocenylalkyl Nucleobases Potential Anti-Cancerous Drugs 126 4.4.5 Ferrocenyl Sub-Ordinates of Illudin-M 126 4.4.6 Ferrocenyl Derivatives of Retinoids Potential Anti-Tumor Drug 127 4.4.7 Targeting Breast Cancer With Selective Ferrocene-Based Estrogen Receptor Modulators (SERM) 128 4.5 Conclusion 131 4.6 Future of Ferrocene-Based Drugs 131 References 132 5 Recent Advances in Cobalt Derived Complexes as Potential Therapeutic Agents 137 Manzoor Ahmad Malik, Ovas Ahmad Dar and Athar Adil Hashmi 5.1 Introduction 137 5.2 Cobalt Complexes as Potential Therapeutic Agents 138 5.3 Conclusion 153 References 154 6 NO-, CO-, and H2S-Based Metallopharmaceuticals 157 R. C. Maurya and J. M. Mir 6.1 Introduction 158 6.2 Signaling Molecules: Concept of “Gasotransmitter” 160 6.2.1 Therapeutic Applications of NO, CO, and H2S 162 6.2.1.1 Exogenous NO Donating Molecules 163 6.3 NO Donors Incorporated in Polymeric Matrices 167 6.3.1 Metal Nitrosyl Complexes 168 6.3.1.1 Sodium Nitroprusside (SNP) 168 6.4 Dinitrosyl Iron Thiol Complexes (DNICs) 170 6.5 Photoactive Transition Metal Nitrosyls as NO Donors 170 6.6 Exogenous CO Donating Molecules 173 6.7 H2S Donating Compounds 176 6.7.1 H2S Gas: A Fast Delivering Compound 176 6.7.2 Sulfide Salts: Fast Delivering H2S Compounds 177 6.7.3 Synthetic Moieties 178 6.7.3.1 Slow-Delivering H2S Compounds 178 6.7.3.2 H2S-Releasing Composite Compounds 179 6.7.4 Naturally Occurring Plant Derived Compounds 182 6.7.4.1 Garlic 182 6.7.4.2 Broccoli and Other Cruciferous Vegetables 184 6.8 Concluding Remarks and Future Outlook 185 References 186 7 Platinum Complexes in Medicine and in the Treatment of Cancer 203 Rakesh Kumar Ameta and Parth Malik 7.1 What is Cancer? 203 7.1.1 Characteristic Features of Cancer Cells 205 7.1.2 Definition of Anticancer Compound 206 7.1.3 Anticancer Attributes of Pt Complexes 207 7.1.4 Native State Behavior of Pt Complexes 208 7.2 Compatibility of Pt Compounds in Cancer Treatment 209 7.2.1 Significance of DNA as Primary Target 209 7.2.2 Kinetics of DNA Binding Activities 210 7.2.3 Structural and Regioselectivity of DNA Adducts 210 7.2.4 Studies on Action Mechanism 211 7.3 Pt Complexes as Anticancer Drugs 214 7.3.1 DNA-Coordinating Pt(II) Complexes 214 7.3.2 DNA-Covalently Binding Pt(II) Complexes 219 7.3.3 Targeted Pt(II) Complexes 222 7.3.4 Pt(IV) Prodrugs 224 7.3.5 Multiple Action of Pt(IV) Prodrugs 225 7.3.6 Targeted Pt(IV) Prodrugs 228 7.3.7 Photodynamic Killing of Cancer Cell by Pt Complexes 231 7.4 Conclusion 231 Acknowledgments 232 References 232 8 Recent Advances in Gold Complexes as Anticancer Agents 247 Mohammad Nadeem Lone, Zubaid-ul-khazir, Ghulam Nabi Yatoo, Javid A. Banday and Irshad A. Wani 8.1 Introduction 248 8.2 Evolution of Metal Complexes as Anticancer Agents 250 8.3 Gold Complexes 251 8.3.1 Complexes with Nitrogen Donar Ligands 252 8.3.2 Complexes with Sulphur Donar Ligands 254 8.3.3 Complexes with Phosphorus Donar Ligands 255 8.3.4 Complexes with Sulphur-Phosphorus Donar Ligands 256 8.3.5 Organometallic Gold Complexes 259 8.3.6 Miscellaneous 260 8.4 Nano-Formulations of Gold Complexes 262 8.5 Future Challenges and Perspectives 263 8.6 Conclusion 265 Acknowledgements 266 References 266 9 Recent Developments in Small Molecular HIV-1 and Hepatitis B Virus RNase H Inhibitors 273 Fenju Wei, Dongwei Kang, Luis Menéndez-Arias, Xinyong Liu and Peng Zhan 9.1 Introduction 273 9.1.1 Activity and Function of HIV and HBV RNases H 274 9.1.2 The Metal-Chelating RNase H Active Site 274 9.2 RNase H Inhibitors and Strategies in the Discovery of Active Compounds 276 9.2.1 High-Throughput Screening 276 9.2.2 Design Based on Pharmacophore Models 278 9.2.3 Novel Inhibitors Obtained by Using “Click Chemistry” 279 9.2.4 Dual-Target Inhibitors Against HIV-1 Integrase (IN) and RNase H 280 9.2.5 Inhibitors Obtained by Using Privileged Fragment-Based Libraries 282 9.2.6 RNase H Inhibitors in Natural Products 283 9.2.7 Drug Repurposing Based on Privileged Structures 284 9.3 Conclusion 286 References 287 10 The Role of Metals and Metallodrugs in the Modulation of Angiogenesis 293 Mehmet Varol and Tuğba Ören Varol 10.1 Introduction 294 10.2 Metallodrugs in Anticancer Therapy 297 10.3 Angiogenesis as a Substantial Target of Tumorigenesis 300 10.4 Metals and Metallodrugs in Angiogenesis 302 10.5 Concluding Remarks and Future Prospects 306 References 306 11 Metal-Based Cellulose: An Attractive Approach Towards Biomedicine Applications 319 Kulsoom Koser and Athar Adil Hashmi 11.1 Introduction 320 11.2 History of Cellulose 320 11.3 The Properties and Structure of Cellulose 321 11.4 Modification of Cellulose 322 11.4.1 Acid Hydrolysis 322 11.4.2 Oxidation 324 11.4.3 Esterification 326 11.4.4 Amidation 331 11.4.5 Carbamiation 333 11.4.6 Etherification 336 11.4.7 Nucleophilic Substitution 339 11.4.8 Further Modification 341 11.5 Present and Future Medical Applications of Cellulose as Well as Its Components 344 11.5.1 Cellulose Used as Wound Dressing 344 11.5.2 Dental Applications 345 11.5.3 Engineering 346 11.5.4 Controllable Drug Delivery System 348 11.5.5 Blood Purification 348 11.5.6 Wrapping Purpose 350 11.5.7 Renal Failure 351 11.6 Conclusion 351 References 352 12 Multifunctional Nanomedicine 363 Nobel Tomar, Maroof A. Hashmi and Athar Adil Hashmi 12.1 Introduction 364 12.2 Diagnostics and Imaging 366 12.3 Drug Delivery and Therapy 369 12.3.1 Drug Delivery by Organic Nanomaterials 369 12.3.1.1 Liposomal Drug Delivery 369 12.3.1.2 Polymeric Drug Delivery 371 12.3.1.3 Proteins and Peptides for Drug Delivery 373 2.3.2 Drug Delivery by Inorganic Nanomaterials 374 12.3.2.1 Metal and Metal Oxides 374 12.3.2.2 Au NPs 375 12.3.2.3 Carbon-Based NPs 375 12.3.2.4 Silicon-Based Nanostructures for Drug Delivery 378 12.3.3 Photo Therapy 379 12.3.3.1 Photodynamic Therapy 380 12.3.3.2 Photothermal Therapy 381 12.3.4 Radiation Therapy 383 12.3.5 Neutron Capture Therapy 384 12.4 Regenerative Medicine 385 12.5 Future Prospects and Conclusion 386 References 387 Index 403

Autorenportrait

Shahid-ul-Islam is a Principal Project Scientist at the Indian Institute of Technology Delhi, where he works on the chemistry of metal-based natural dyes using advanced technologies. He received his PhD in Chemistry from Jamia Millia Islamia (A Central University), New Delhi, India, in 2017. He has to his credit several research journal publications, patents and books with the Wiley-Scrivener imprint. Athar Adil Hashmi studied chemistry at Aligarh Muslim University, India and obtained his PhD in 1994. From 1990 to 2007 he held positions at the department of chemistry, Jamia Millia Islamia (Central University), New Delhi, India. Since April 2017 he is working as a visiting Professor at King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia. His work area includes organometallic chemistry, metal containing polymers and bio-inorganic chemistry. Along with his international publications, book chapters, he has guided 30 postgraduate projects and 13 PhD students. Salman Ahmad Khan received his PhD in Organic Chemistry from the Jamia Millia Islamia (JMI) (A Central University), New Delhi, India, in 2007. Since 2009 he has been with the Department of Chemistry, King Abdulaziz University, Jeddah, Saudi Arabia, where he is an Associate Professor. His current research interests include Heterocyclic Chemistry, Chromones, Chalcones, Anthraquinones, Photophysical, Physicochemical, Multi steps reactions, one pot multi component synthesis and Nanotechnology. Dr. Salman is an active researcher and has published more than 100 research articles in various reputed international journals.

Back cover copy

The book provides a recent update and achievements in the preparation and application of newly designed metal-based drugs. Over the past few decades, medicinal inorganic chemistry as an interdisciplinary sub-area of bioinorganic chemistry, has received a growing attention of researchers in the search for promising antimicrobial, antimalarial, antiviral, and antitumor chemotherapeutic agents. An excellent compilation of reports on metal complexes has revealed the potency of metal complexes as better therapeutic agents. Metal-containing drugs have several promising advantages over organic ligands and have gained the trust of researchers after the worldwide approval of the drug cisplatin. Their distinct mechanism of action makes them perfect candidates as alternatives to the conventional drugs to which resistance has already been shown. In this direction, a huge number of transition metal complexes have been synthesized and evaluated for their biological profiles. This book is organized into 12 important chapters that focus on the progress made by metal-based drugs as anticancer, antibacterial, antiviral, anti-inflammatory, and anti-neurodegenerative agents, as well as highlighting the application areas of newly discovered metallodrugs. This important and topical book: <ul> <li>Discusses newly adopted methods involved in the design of effective metallodrugs</li> <li>Provides up-to-date developments in the application of metal-complex drugs</li> <li>Discusses the role of metallodrugs as promising chemotherapeutic agents</li> </ul> Audience The book will be used extensively by researchers, engineers, and postgraduate students working in the fields of medical science, pharmacy, biotechnology and biomedical engineering.